Introduction.
As I wrote formerly (1), till July 1st, 2011, water memory was an argument of large discussion, really a conjecture.
In fact, nobody has ever proved that water is able of retaining a memory (I use also the term INFORMATION) of substances dissolved in it once to arbitrary dilution. In the referred paper, precise information on utilizing Water Memory-Information was provided.
While some studies, including Benveniste’s, reported this effect, double-blind replications of the experiments involved have failed to reproduce the results, and the concept is not accepted by the scientific community.
On the contrary, I illustrated the CLINICAL, Quantum Biophysical Semeiotic Demonstration of Water Memory-Information, curing my gastroenterocolitis due to Gram-positive bacteria, I had been suffering from for 4 days (1).
Importantly, every my experimental evidence can be bedside reproduced easily and quickly, at the condition that scientists, who want reproduce it, know the quantum biophysical semeiotic method!
For 4 decades I have been suffering from Chronic Fatigue Syndrome (CFS), an unsolved therapeutic problem till now. Thanks to earlier treatment, based on free-radicals scavenger and anti-inflammatory drugs, I obtained partial and transitory benefit (2-8).
Chronic Fatigue Syndrome: State of the Art.
Chronic fatigue syndrome, CFS, is a debilitating and complex disorder characterized by profound fatigue that is not improved by bed rest and that may be worsened by physical or mental activity. Persons with CFS most often function at a substantially lower level of activity than they were capable of before the onset of the illness.
The fatigue of CFS is accompanied by characteristic symptoms lasting at least 6 months, including self-reported impairment in short-term memory or concentration, severe enough to cause substantial reduction in previous levels of occupational, educational, social, or personal activities; sore throat is frequent or recurring; tender cervical (neck) or axillary lymph nodes; muscle pain; multi-joint pain without swelling or redness; headaches of a new type, pattern, or severity; very common un-refreshing sleep and post-exertional malaise (extreme, prolonged exhaustion and sickness following physical or mental activity) lasting more than 24 hours.
However, many CFS patients may experience other symptoms, including irritable bowel, depression or psychological problems, chills and night sweats, visual disturbances, allergies or sensitivities to food, odours, chemicals, medications, or noise, brain fog, difficulty maintaining upright position, dizziness, balance problems or fainting.
CFS: the hypothesis 0, I cannot falsify.
Quantum Biophysical Semeiotics facilitates CFS diagnosis, as illustrated here after.
The hypothesis 0 to falsify was that in CFS skeletal muscles, a part from the possible causes of such a disorder, are altered from the structural and functional view-point: structure and function are two poles of the same equation!
As a consequence the relative energy frequency, gathered from skeletal muscles, e.g., biceps and quadriceps, was altered, too, so that after modifying it properly with Cem Tech, and retransmitting it to a glass of mineral water that patients swallow, physicians will ameliorate until normalize their muscle structure and function, especially regarding local mitochondria respiratory activity, altered in CFS.
As a matter of fact, such a water, thanks to Cem Tech, contains Information on the muscle physiological structure, conserving it as Memory for a time to prove – two days after the experiment beginning – results are present yet, as I am going to illustrate here after.
Quantum Biophysical Semeiotic Methods.
Basal QBS evaluation showed that, under “intense” (= such an adjactive is “quantitative”, rather than “qualitative”, indicating that it brings about upper ureteral reflex, typical of Artero-Venous Anastomoses (AVA) type A, group II, according to Bucciante) (19-13) digital pressure, latency time of (biceps and quadriceps) skeletal muscle-gastric aspecific reflex was 9 sec. (NN = 10 sec.); duration pathologically increased to 7 sec. (NN > 3 sec. < 4 sec.; paramount parameter value, paralleling the efficiency of local Microcirculatory Reserve Function); finally, the time of reflex disappearing lowered to 3 sec. (NN > 3 sec. < 4 sec., perfectly identical to fractal Dimension of local microvessel fluctuation, calculated in a really refined, but difficult, way) (9-12).
In addition, the Free-Radical QBS evaluation resulted positive, emphasising an high tissue level of oxygen reactive substances (8): at the second assessment, exactly 3 sec. after the basal evaluation, latency time of muscle-gastric aspecific reflex decreased pathologically to 7,5 sec.
At this point, I have captured with Cem Tech two devices (crystals) frequency from my right biceps and respectively from my left quadriceps, for 1 minute.
Subsequently, after applying the two devices on myself on the same sites, cited above, I assessed for the second time the identical parameter values of skeletal muscle-gastric aspecific reflex.
Latency time of the reflex raised to 20 sec. (basal value = 9 sec.), as it happens in QBS physiological preconditioning (11, 12). Reflex duration decreased to 3 sec., showing a perfect muscle vessels Microcirculatory Functional Reserve. Finally, the time of reflex disappearing returned to normal value: > 3 sec. < 4 sec.
At this moment, I removed from my body Cem Tech crystals, emitting extremely high energy frequency, and immediately reflex parameters showed identical pathological parameter value, as those observed in basal examination, referred above.
At this point, I directed the extremely high frequency energy, contained by Cem Tech devices, towards the water, precisely mineral water, present in a glass, placed on the table 10 cm from my body, by applying the two crystals directly on the base of glass bottom for 10 min.
Starting from about 4 minutes, parameter values of the above illustrated reflex progressively ameliorated, and after less than 10 sec. they showed the values, typical of QBS physiological preconditioning.
Every observation was possible thank to, and enlightened by, n-DNA and mit-DNA Antenna theory, I demonstrated formerly (14, 15).
At this point, I went away from the water in the glass, as well as from Cem Tech devices: the evaluation of reflex parameter values resulted again in pathological ranges, showing the same data, referred above!
Soon after I drunk that energized water, I observed identical, significant increasing of all parameter values of muscle-gastric aspecific reflex: Latency time of the reflex raised to 20 sec. (basal value 9 sec.), characteristic of QBS preconditioning (11, 12). Reflex duration lowered to 3 sec., showing a perfect Microcirculatory Functional Reserve of muscle microcirculatory bed.
Finally, the time of reflex disappearing returned to normal value: > 3 sec. < 4 sec.;
Importantly, the cleaned glass was inactive, i.e., it did not bring about increasing of reflex parameter values!
Interestingly, two hours after the experiment beginning, all parameter values, illustrated above, were yet identical. I walked for 45 min. without feeling fatigue, like now while I am writing this Manuscript. Benveniste was right!
Interestingly, the above illustrated positive results lasted exactly for 14 hours; then all parameters values slowly decreased in the three subsequent hours until the latency time of skeletal muscle reflex decreased to 12 sec. (NN = 10 sec.); reflex duration lowered to 3 sec. (NN >3 sec.< 4 sec. indicating a perfect Microcirculatory Functional Reserve); finally, reflex disappearing time was 4 sec., showing that fractal Dimension of local microvessels oscillations was at highest value.
After two days all parameters showed normal values.
Conclusion: the significant data of this quantum-biophysical-semeiotic experiment, illustrated in details from the technical view-point, aiming to treat Chronic Fatigue Syndrome, allows me to state that a “possible”, really efficacious therapy of CFS has been discovered, if it will be corroborated on a very large scale, of course.
References
1) Stagnaro Sergio. First Water Memory-Information Demonstration through Quantum Biophysical Semeiotics. 1 July, 2011, http://stagnaro.wordpress.com/ ; http://www.sisbq.org/journal-of-quantum-biophysical-semeiotics1.html; http://www.sisbq.org/uploads/5/6/8/7/5687930/watermemoryinformation.pdf
2) Stagnaro-Neri M., Stagnaro S., Carenza di Co Q10 secondaria a terapia ipolipidemizzante diagnosticata con la Percussione Ascoltata. Settimana Italiana di Dietologia, 9-13 Aprile 1991, Merano. Atti, pg. 65. Epat. 37, 17, 1990.
2) Stagnaro-Neri M., Stagnaro S., Acidi grassi ώ-3, scavengers dei radicali liberi e attivatori del ciclo Q della sintesi del Co Q10. Gazz. Med. It. – Arch. Sc. Med. 151, 341, 1992.
3) Stagnaro-Neri M., Stagnaro S., Auscultatory Percussion Coenzyme Q deficiency Syndrome. VI Int. Symp., Biomedical and clinical aspects of Coenzyme Q. Rome, January 22.24, 1990,Chairmen K. Folkers, G.L. Littarru, T. Yamagani, Abs., pg. 105.
4) Stagnaro-Neri M., Stagnaro S., Sindrome clinica percusso-ascoltatoria da carenza di Co Q10. Medic. Geriatr. XXIV, 239.
5) Stagnaro-Neri M, Stagnaro S. Co Q10 in the prevention and treatment of primary osteoporosis. Preliminary data. Clin Ter.;146(3):215-9 [MEDLINE]
6) Stagnaro-Neri M., Stagnaro S., La sindrome percusso-ascoltatoria da carenza di Carnitina. Clin. Ter. 145, 135, 1994 [Medline]
7) Stagnaro-Neri M., Stagnaro S., La sindrome percusso-ascoltatoria da carenza di Carnitina. Clin. Ter. 145, 135, 1992 [Medline]
8) Stagnaro-Neri M., Stagnaro S., Ketanserina: antagonista dei recettori 5Ht2-serotoninergici e scavenger dei radicali liberi. Clin. Ter. 141, 465, 1994 [Medline]
9) Stagnaro-Neri M., Stagnaro S., Deterministic chaotic biological system: the microcirculatoory bed. Theoretical and practical aspects. Gazz. Med. It. – Arch. Sc. Med. 153, 99
10) Stagnaro-Neri M., Moscatelli G., Biophysical Semeiotics: deterministic Chaos and biological Systems. Gazz. Med. It. – Arch. Sc. Med. 155, 125, 1996.
11) Stagnaro-Neri M., Stagnaro S., Deterministic Chaos, Preconditioning and Myocardial Oxygenation evaluated clinically with the aid of Biophysical Semeiotics in the Diagnosis of ischaemic Heart Disease even silent. Acta Med. Medit. 13, 109, 1997.
12) Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning - c007i. Lecture, V Virtual International Congress of Cardiology. 2007. http://www.fac.org.ar/qcvc/llave/c007i/stagnaros.php
13) Stagnaro-Neri M., Stagnaro S., Auscultatory Percussion Evaluation of Arterio-venous Anastomoses Dysfunction in early Arteriosclerosis. Acta Med. Medit. 5, 141, 1989.
14) Sergio Stagnaro. Ruolo del DNA Antenna nella Diagnosi Semeiotica Biofisica Quantistica dei Primi due Stadi del Diabete Mellito tipo 2. http://www.fcenews.it, 19 novembre 2010. http://www.fceonline.it/images/docs/dna_diabete.pdf; http://qbsemeiotics.weebly.com/uploads/5/6/8/7/5687930/dna_t2dm.pdf
15) Simone Caramel and Sergio Stagnaro The role of glycocalyx in QBS diagnosis of Di Bella’s Oncological Terrain - http://www.sisbq.org/uploads/5/6/8/7/5687930/oncological_glycocalyx2011.pdf
giovedì 7 luglio 2011
martedì 5 luglio 2011
Gentile’s Sign*: Bedside Diagnosing Acute Myocardial Infarction, even initial or silent.
Bedside diagnosing Acute Myocardial Infarction (AMI) is sometimes very difficult, particularly if initial or silent. On the other hand, the efficaciousness of therapeutic results, especially regarding mortality rate, depend of early AMI diagnosis (1-7).
In following, a Quantum Biophysical Semeiotics simple method, easily and quickly to apply, based on Gentile’s Sign, is fully illustrated.
Considering that glucose and lipid metabolism impairment worsens, BUT not brings about coronary artery disease (CAD), as I have demonstrated earlier (3-8), physician has to know CAD Inherited Real Risk, rapidly detected with the Caotino’s Sign (8), representing the condition sine qua non of CAD, especially in individuals involved by hypertension, diabetes mellitus, dyslipidemia, or elevated C-reactive protein.
In my long, well-established clinical experience, Gentile’s Sign proved to be really useful also in order to bed-side recognizing AMI, even silent or initial: impending infarction.
Importantly, it is known that patients with CAD may have no symptoms at all for many years or decades and that the electrocardiographic features of ischemia may be induced by exercise without accompanying angina (2, 7, 8). As a consequence, physicians need a clinical tool reliable in rapid detecting CAD, even clinically silent, initiating from CAD “inherited real risk. From the practical viewpoint, in order to apply Gentile’s Sign doctor has to know, at least, the auscultatory percussion of the stomach (1).
In health, digital pressure of “mean” intensity (= stimulation of both upper and lower ureteral reflex: vasomotility and respectively vasomotion, according to Hammersen), applied upon ventricle heart skin projection area = precordium), brings about the so-called gastric aspecific reflex (= in the stomach, fundus and body are dilated, while antral-pyloric region contracts) after a latency time of 8 sec. exactly; reflex duration is less than 4 sec. (= parameter value of paramount significance since it parallels the efficacy of local coronary microvessel Microcirculatory Functional Reserve). Finally, the reflex disappearing is > 3 sec. < 4 sec. (= parameter value paralleling fractal Dimension of local microcirculatory oscillations) (1-4) (Fig. 1).
On the contrary, in impending infarction and obviously in overt AMI, even silent or initial, latency time appears significantly lowered to 3-5 sec, in inverse relation with the seriousness of underlying disorder (NN = 8 sec.). Reflex lasts longer than normal: 4 sec. or more (NN = > 3 sec. < 4 sec.), directly correlated with the AMI severity.
Finally, nail-digital pressure on identical heart trigger-points, illustrated above, only in AMI patients bring about gastric aspecific refelex after a reduced latency time: 3-5 sec. (NN = 10 sec. or more)
When physicians will be able to apply Gentile’s Sign, and Caotino’s Sign, both morbidity and mortality caused by AMI will lowered significantly, and CAD will not be, as nowadays, a growing epidemics.
*Anna Gentile, MD. My Cardiologist, Sestri Levante Hospital, ASL 4, (Genova) Italy
References
1)Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Ed. Travel Factory, Roma, 2004. http://www.travelfactory.it/ semeiotica_biofisica.htm
2)Stagnaro-Neri M., Stagnaro S., Deterministic Chaos, Preconditioning and Myocardial Oxygenation evaluated clinically with the aid of Biophysical Semeiotics in the Diagnosis of ischaemic Heart Disease even silent. Acta Med. Medit. 13, 109, 1997.
3)Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning - c007i. Lecture, V Virtual International Congress of Cardiology. http://www.fac.org.ar/qcvc/llave/c007i/stagnaros.php
4)Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico- Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Travel Factory, Roma, 2004
5) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it, Roma, 2009.
6)Stagnaro S. Epidemiological evidence for the non-random clustering of the components of the metabolic syndrome: multicentre study of the Mediterranean Group for the Study of Diabetes. Eur J Clin Nutr. 2007 Feb 7; [MEDLINE]
7) Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn- Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. www.athero.org, 29 April, 2009 http://www.athero.org/commentaries/comm907.asp
8) Sergio Stagnaro. Caotino’s Sign in bedside detecting CAD, since its initial Stage of CAD Inherited Real Risk. www.fce.it. 3 giugno 2010. http://www.fceonline.it/images/docs/caotino.pdf
In following, a Quantum Biophysical Semeiotics simple method, easily and quickly to apply, based on Gentile’s Sign, is fully illustrated.
Considering that glucose and lipid metabolism impairment worsens, BUT not brings about coronary artery disease (CAD), as I have demonstrated earlier (3-8), physician has to know CAD Inherited Real Risk, rapidly detected with the Caotino’s Sign (8), representing the condition sine qua non of CAD, especially in individuals involved by hypertension, diabetes mellitus, dyslipidemia, or elevated C-reactive protein.
In my long, well-established clinical experience, Gentile’s Sign proved to be really useful also in order to bed-side recognizing AMI, even silent or initial: impending infarction.
Importantly, it is known that patients with CAD may have no symptoms at all for many years or decades and that the electrocardiographic features of ischemia may be induced by exercise without accompanying angina (2, 7, 8). As a consequence, physicians need a clinical tool reliable in rapid detecting CAD, even clinically silent, initiating from CAD “inherited real risk. From the practical viewpoint, in order to apply Gentile’s Sign doctor has to know, at least, the auscultatory percussion of the stomach (1).
In health, digital pressure of “mean” intensity (= stimulation of both upper and lower ureteral reflex: vasomotility and respectively vasomotion, according to Hammersen), applied upon ventricle heart skin projection area = precordium), brings about the so-called gastric aspecific reflex (= in the stomach, fundus and body are dilated, while antral-pyloric region contracts) after a latency time of 8 sec. exactly; reflex duration is less than 4 sec. (= parameter value of paramount significance since it parallels the efficacy of local coronary microvessel Microcirculatory Functional Reserve). Finally, the reflex disappearing is > 3 sec. < 4 sec. (= parameter value paralleling fractal Dimension of local microcirculatory oscillations) (1-4) (Fig. 1).
On the contrary, in impending infarction and obviously in overt AMI, even silent or initial, latency time appears significantly lowered to 3-5 sec, in inverse relation with the seriousness of underlying disorder (NN = 8 sec.). Reflex lasts longer than normal: 4 sec. or more (NN = > 3 sec. < 4 sec.), directly correlated with the AMI severity.
Finally, nail-digital pressure on identical heart trigger-points, illustrated above, only in AMI patients bring about gastric aspecific refelex after a reduced latency time: 3-5 sec. (NN = 10 sec. or more)
When physicians will be able to apply Gentile’s Sign, and Caotino’s Sign, both morbidity and mortality caused by AMI will lowered significantly, and CAD will not be, as nowadays, a growing epidemics.
*Anna Gentile, MD. My Cardiologist, Sestri Levante Hospital, ASL 4, (Genova) Italy
References
1)Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Ed. Travel Factory, Roma, 2004. http://www.travelfactory.it/ semeiotica_biofisica.htm
2)Stagnaro-Neri M., Stagnaro S., Deterministic Chaos, Preconditioning and Myocardial Oxygenation evaluated clinically with the aid of Biophysical Semeiotics in the Diagnosis of ischaemic Heart Disease even silent. Acta Med. Medit. 13, 109, 1997.
3)Stagnaro Sergio. Role of Coronary Endoarterial Blocking Devices in Myocardial Preconditioning - c007i. Lecture, V Virtual International Congress of Cardiology. http://www.fac.org.ar/qcvc/llave/c007i/stagnaros.php
4)Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico- Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Travel Factory, Roma, 2004
5) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it, Roma, 2009.
6)Stagnaro S. Epidemiological evidence for the non-random clustering of the components of the metabolic syndrome: multicentre study of the Mediterranean Group for the Study of Diabetes. Eur J Clin Nutr. 2007 Feb 7; [MEDLINE]
7) Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn- Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. www.athero.org, 29 April, 2009 http://www.athero.org/commentaries/comm907.asp
8) Sergio Stagnaro. Caotino’s Sign in bedside detecting CAD, since its initial Stage of CAD Inherited Real Risk. www.fce.it. 3 giugno 2010. http://www.fceonline.it/images/docs/caotino.pdf
lunedì 4 luglio 2011
Without Diabetic Quantum Biophysical Semeiotic Constituion DM cannot occurs!
My 55 year long clinical experience allows me to state that type 1 and 2 DM is based on a mitochondrial cytopathology, I named Congenital Acidosic Enzyme-Metabolic Histangiopathy, i.e., CAEMH (See my website www.semeioticabiofisica.it, Diabetes Mellitus, 6 articles) (!-5). In addition, CAEMH can bring about "all" biophysical semeiotic constitutions, including both the "diabetic and the dyslipidemic" ones: type 2 DM can occur solely in presence of the TWO constitutions, according to Joslin's old, but corroborated, theory (See above-cited 5 articles). Interestingly, if mother is positive for diabetic constitution, but father not, and the child is physically alike the father, in 50% of cases, ther is not predisposition to DM.
As mitochondrial cytopathology, ONLY mather can transmit these predispositions, but not father. Therefore, offspring of diabetic father (but NOT mother), were obviously "healthy" individuals!
As mitochondrial cytopathology, ONLY mather can transmit these predispositions, but not father. Therefore, offspring of diabetic father (but NOT mother), were obviously "healthy" individuals!
sabato 14 maggio 2011
Functional Decline in Aging , Brain Inherited Real Risk, and Co Q10 Deficiency Syndrome.
Original Message -----
From: "JCI Editors"
To:
Sent: Wednesday, March 30, 2011 10:32 PM
Subject: Fwd: Fwd: What do you think?
Dear Dr. Stagnaro,
Thank you for your presubmission inquiry. Unfortunately, the Editors did
not feel that submission of your manuscript to the Journal of Clinical
Investigation would be appropriate at this time.
As we are able to only review a fraction of the manuscripts submitted to
the JCI, we must keep in mind how well your manuscript would compete
with the many others we receive. Your proposal was carefully evaluated,
and we determined that it would not ultimately be successful upon formal
review. In making this decision we do not mean to imply a criticism of
the work, we simply question its appropriateness for the JCI.
We thank you for giving us the opportunity to read about your work, and
hope you are soon able to interest an alternate journal in your manuscript.
Sincerely,
Ushma S. Neill, Ph.D.
Executive Editor
In following, I would like emphasise briefly the central role of these quantum-biophysical-semeiotic-Constitution-Dependent, Inherited Real Risk of Brain also in aging people disease occurrence,especially if Co Q10 deficiency is present.
In my opinion, bedside quantum-biophysical-semeiotic diagnosis of Co Q10 deficiency syndrome, I have described earlier (1-5), and the topic of above-cited Letter to Editors, could be very helpful in risk stratification to predict functional decline in Older Adults.
In fact, I have demonstrated that doctors can clinically recognize with the aid of a stethoscope subjects involved by Ubidecarenone deficiency, even initial and symptomless, causing damage of tissues due to the increase levels of free radical (1-5).
Moreover, in my 55-long clinical experience, such as diagnosis, made clinically for the first time, proved to be really efficacious and reliable in avoiding dangerous administration of statine to individuals without clinical symptomatology, even involved by ubidecarenone deficiency, notoriously worsened by anti-cholesterolemic drugs.
In addition, physicians are able to recognize since birth whatever Constitution-Dependent Inherited quantum-biophysical-semeiotic Real Risk, including oncological, diabetic, and Alzheimer Disease one (5-8), based on microvascular remodelling, characterized by newborn-pathological, type I, subtype a), oncological, and b) aspecific Endoarteriolar Blocking Devices, which predispose to the related disorders.
Finally, only individuals with inherited cerebral quantum-biophysical-semeiotic Inherited Real Risk (5) may be involved by functional decline, like Alzheimer Disease (8), particularly in presence of Co Q10 deficincy syndrome.
References
1) Stagnaro-Neri M., Stagnaro S., Carenza di Co Q10 secondaria a terapia ipolipidemmizante diagnosticata con la Percussione Ascoltata. Settimana Italiana di Dietologia, 9-13 Aprile 1991, Merano. Atti, pg. 65. Epat. 37, 17, 1990.
2)Stagnaro-Neri M., Stagnaro S., Acidi grassi W-3, scavengers dei radicali liberi e attivatori del ciclo Q della sintesi del Co Q10. Gazz. Med. It. – Arch. Sc. Med. 151, 341, 1992.
3) Stagnaro-Neri M., Stagnaro S., Auscultatory Percussion Coenzyme Q deficiency Syndrome. VI Int. Symp., Biomedical and clinical aspects of Coenzyme Q. Rome, January 22.24, 1990,Chairmen K. Folkers, G.L. Littarru, T. Yamagani, Abs., pg. 105.
4) Stagnaro-Neri M., Stagnaro S., Sindrome clinica percusso-ascoltatoria da carenza di Co Q10. Medic. Geriatr. XXIV, 239.
5) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it, Roma, 2009.
6) Stagnaro S. Bedside diagnosis of osteoporotic constitution, real risk of inheriting ostoporosis, and finally osteoporosis. Theoretical Biology and Medical Modelling 21 June 2007. http://www.tbiomed.com/content/4/1/23/comments#285569
7) Stagnaro S. New bedside way in reducing mortality in diabetic men and women. Ann. Int. Med. . http://www.annals.org/cgi/eletters/0000605-200708070-00167v1
8) Stagnaro Sergio. Alzheimer's Disease Byophysical Semeiotics supports the pathophysiology of Koudinov's theory.11 January 2002. Clin. Med. & Health Research http://clinmed.netprints.org/cgi/eletters/2001100005v1#9
From: "JCI Editors"
To:
Sent: Wednesday, March 30, 2011 10:32 PM
Subject: Fwd: Fwd: What do you think?
Dear Dr. Stagnaro,
Thank you for your presubmission inquiry. Unfortunately, the Editors did
not feel that submission of your manuscript to the Journal of Clinical
Investigation would be appropriate at this time.
As we are able to only review a fraction of the manuscripts submitted to
the JCI, we must keep in mind how well your manuscript would compete
with the many others we receive. Your proposal was carefully evaluated,
and we determined that it would not ultimately be successful upon formal
review. In making this decision we do not mean to imply a criticism of
the work, we simply question its appropriateness for the JCI.
We thank you for giving us the opportunity to read about your work, and
hope you are soon able to interest an alternate journal in your manuscript.
Sincerely,
Ushma S. Neill, Ph.D.
Executive Editor
In following, I would like emphasise briefly the central role of these quantum-biophysical-semeiotic-Constitution-Dependent, Inherited Real Risk of Brain also in aging people disease occurrence,especially if Co Q10 deficiency is present.
In my opinion, bedside quantum-biophysical-semeiotic diagnosis of Co Q10 deficiency syndrome, I have described earlier (1-5), and the topic of above-cited Letter to Editors, could be very helpful in risk stratification to predict functional decline in Older Adults.
In fact, I have demonstrated that doctors can clinically recognize with the aid of a stethoscope subjects involved by Ubidecarenone deficiency, even initial and symptomless, causing damage of tissues due to the increase levels of free radical (1-5).
Moreover, in my 55-long clinical experience, such as diagnosis, made clinically for the first time, proved to be really efficacious and reliable in avoiding dangerous administration of statine to individuals without clinical symptomatology, even involved by ubidecarenone deficiency, notoriously worsened by anti-cholesterolemic drugs.
In addition, physicians are able to recognize since birth whatever Constitution-Dependent Inherited quantum-biophysical-semeiotic Real Risk, including oncological, diabetic, and Alzheimer Disease one (5-8), based on microvascular remodelling, characterized by newborn-pathological, type I, subtype a), oncological, and b) aspecific Endoarteriolar Blocking Devices, which predispose to the related disorders.
Finally, only individuals with inherited cerebral quantum-biophysical-semeiotic Inherited Real Risk (5) may be involved by functional decline, like Alzheimer Disease (8), particularly in presence of Co Q10 deficincy syndrome.
References
1) Stagnaro-Neri M., Stagnaro S., Carenza di Co Q10 secondaria a terapia ipolipidemmizante diagnosticata con la Percussione Ascoltata. Settimana Italiana di Dietologia, 9-13 Aprile 1991, Merano. Atti, pg. 65. Epat. 37, 17, 1990.
2)Stagnaro-Neri M., Stagnaro S., Acidi grassi W-3, scavengers dei radicali liberi e attivatori del ciclo Q della sintesi del Co Q10. Gazz. Med. It. – Arch. Sc. Med. 151, 341, 1992.
3) Stagnaro-Neri M., Stagnaro S., Auscultatory Percussion Coenzyme Q deficiency Syndrome. VI Int. Symp., Biomedical and clinical aspects of Coenzyme Q. Rome, January 22.24, 1990,Chairmen K. Folkers, G.L. Littarru, T. Yamagani, Abs., pg. 105.
4) Stagnaro-Neri M., Stagnaro S., Sindrome clinica percusso-ascoltatoria da carenza di Co Q10. Medic. Geriatr. XXIV, 239.
5) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it, Roma, 2009.
6) Stagnaro S. Bedside diagnosis of osteoporotic constitution, real risk of inheriting ostoporosis, and finally osteoporosis. Theoretical Biology and Medical Modelling 21 June 2007. http://www.tbiomed.com/content/4/1/23/comments#285569
7) Stagnaro S. New bedside way in reducing mortality in diabetic men and women. Ann. Int. Med. . http://www.annals.org/cgi/eletters/0000605-200708070-00167v1
8) Stagnaro Sergio. Alzheimer's Disease Byophysical Semeiotics supports the pathophysiology of Koudinov's theory.11 January 2002. Clin. Med. & Health Research http://clinmed.netprints.org/cgi/eletters/2001100005v1#9
venerdì 13 maggio 2011
Do NEJM Editors know Oncological Terrain? Vitamine D and Cancer Primary Prevention. Oncological Terrain plays a central Role.
Do NEJM Editors know Oncological Terrain?
Vitamine D and Cancer Primary Prevention. Oncological Terrain plays a central Role.
The following Letter to Editors, date submitted 8 April, 2011 (Manuscript ID: 11-04116. Title:Vitamine D and Cancer. Oncological Terrain plays a central Role. Author: Stagnaro, Sergio. Date Submitted: 08-Apr-2011) has been rejected by NEJM the day 13 May, 2010.
Overlooking the Congenital Acidosic Enzyme-Metabolic Histangiopathy, at base of Oncological Terrain, "conditio sine qua non" of most dangerous human disorders, including malignancy is overlooked, primary preventions are fundamentally biased, and thus no efficacious (1-5). Environmental risk factors and drugs, suggested as cancer risk factors, influence human biological functions, bringing about different disorders, like cancers, exclusively in presence of CAEMH-Dependent Oncological Inherited Real Risk in a biological system. This overlooked functional mitochondrial cytopathology, quantum-biophysical-semeiotic constitutions are based on, is genetic factor of human disorders, including malignancy (1-5). I emphasise pathological negative influence of smoking and Vitamine D deficiency on biological systems (3, 4). This effect varies in prevalence and intensity among individuals in relation to the above-mentioned congenital mitochondrial cytopathology, (2). This "silent" and dangerous action is easy to evaluate at the bed-side with a stethoscope. Physician first investigates the presence of CAEMH in the "enrolled" individuals, and than assesses OT-Dependent Inherited Real Risk, based on above-mentioned congenital cytopathology, characterized by newborn-pathological, type I, subtype a), oncological, Endoarterial Blocking Devices, causing the typical microvascular remodelling (1-5).
References
1) Stagnaro S., Stagnaro-Neri M. Una patologia mitocondriale ignorata: la Istangiopatia Congenita Acidosica Enzimo-Metabolica. Gazz. Med. It. - Arch. Sci. Med. 1990;149: 67-69.
2) Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [MEDLINE]
3) Caramel S., Stagnaro S. The role of mitochondria and mit-DNA in Oncogenesis. http://ilfattorec.altervista.org/mitDNA&oncogenesis_english.pdf; http://www.quantumbiosystems.org/admin/files/QBS 2(1) 250-281.pdf.
4) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Ed. Travel Factory, Roma, 2004. http://www.travelfactory.it/
5) ) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it
Vitamine D and Cancer Primary Prevention. Oncological Terrain plays a central Role.
The following Letter to Editors, date submitted 8 April, 2011 (Manuscript ID: 11-04116. Title:Vitamine D and Cancer. Oncological Terrain plays a central Role. Author: Stagnaro, Sergio. Date Submitted: 08-Apr-2011) has been rejected by NEJM the day 13 May, 2010.
Overlooking the Congenital Acidosic Enzyme-Metabolic Histangiopathy, at base of Oncological Terrain, "conditio sine qua non" of most dangerous human disorders, including malignancy is overlooked, primary preventions are fundamentally biased, and thus no efficacious (1-5). Environmental risk factors and drugs, suggested as cancer risk factors, influence human biological functions, bringing about different disorders, like cancers, exclusively in presence of CAEMH-Dependent Oncological Inherited Real Risk in a biological system. This overlooked functional mitochondrial cytopathology, quantum-biophysical-semeiotic constitutions are based on, is genetic factor of human disorders, including malignancy (1-5). I emphasise pathological negative influence of smoking and Vitamine D deficiency on biological systems (3, 4). This effect varies in prevalence and intensity among individuals in relation to the above-mentioned congenital mitochondrial cytopathology, (2). This "silent" and dangerous action is easy to evaluate at the bed-side with a stethoscope. Physician first investigates the presence of CAEMH in the "enrolled" individuals, and than assesses OT-Dependent Inherited Real Risk, based on above-mentioned congenital cytopathology, characterized by newborn-pathological, type I, subtype a), oncological, Endoarterial Blocking Devices, causing the typical microvascular remodelling (1-5).
References
1) Stagnaro S., Stagnaro-Neri M. Una patologia mitocondriale ignorata: la Istangiopatia Congenita Acidosica Enzimo-Metabolica. Gazz. Med. It. - Arch. Sci. Med. 1990;149: 67-69.
2) Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [MEDLINE]
3) Caramel S., Stagnaro S. The role of mitochondria and mit-DNA in Oncogenesis. http://ilfattorec.altervista.org/mitDNA&oncogenesis_english.pdf; http://www.quantumbiosystems.org/admin/files/QBS 2(1) 250-281.pdf.
4) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Ed. Travel Factory, Roma, 2004. http://www.travelfactory.it/
5) ) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it
mercoledì 11 maggio 2011
Right Planum Temporale Dominance, Congenital Acidosic Enzyme-Metabolic Histangiopathy, Quantum Biophysical Semeiotic Constitutions-Dependent Inherited
Abstract.
In the paper Authors* illustrate briefly the relation between right Planum Temporale dominance, Congenital Acidosic Enzyme-Metabolic Histangiopathy, and Quantum Biophysical Semeiotics Constitutions-Dependent Inherited Real Risks. In addition, Authors emphasise the possibility of bedside recognizing these congenital alterations, starting since birth. Finally, the efficacious Primary Prevention of most common and dangerous disorders is described.
* Sergio Stagnaro, and Simone Caramel
Editors,
in spite of an awful number of papers, one may reading the Literature since 32 years, the right dominant Planum Temporale, typical of Congenital Acidosic Enzyme-Metabolic Histangiopathy, a congenital mitochondrial cytopathy, quantum biohysical semeiotic Constitutions, and thus the relatedInherited Real Risk, bedside recognised with a stethoscope, are based on, is either overlooked or ignored by the majority of physicians, including neurologists. (1-8)
Quantum Biophysics Semeiotics,QBS, is a new discipline in medical field, extension of the classical semeiotics with the support of quantum and complexity theories, a scientific approach first described by Stagnaro (1-8) based on the 'Congenital Acidosic Enzyme-Metabolic Histangiopathy , CAEMH (1-4), a unique mitochondrial cytopathy, present at birth and subject to medical therapy.
According to the research of Stagnaro, today doctors should be able to evaluate, at the bedside, simply using the stethoscope and auscultatory percussion of the stomach (2), mitochondria functionality, as well as thefunctionality of all biological systems. It is now possible, since the moment of birth, to make adiagnosis in order to detect the presence of the Inherited Real Risk of many diseases linked with QBS Constitutions (3), so that an intelligent prevention strategy can be
implemented only on those subjects with Inherited Real Risk.
According to Stagnaro (2-5, 8-10), genome's information are transmitted simultaneously both to parenchyma and related micro-vessels, so that mutations in parenchymal cell n-DNA
and mit-DNA are the conditio sine qua non of the most common human disorders, like diabetes, CAD, and cancer, today's epidemics.
In fact, all these diseases are based on a particular congenital, functional, mitochondrial cytopathy, mostly transmitted through mother, and defined 'Congenital Acidosic Enzyme-
Metabolic Histangiopathy' - CAEMH (8-10).
Quantum Biophysical Semeiotics, in addition to the most severe disease diagnosis as, for example, many solid and liquid forms of cancer, type 2 diabetes mellitus, heart diseases, hypertension, osteoporosis, is concerned to suggest preventive therapies so that, especially in those at risk for some diseases, the still potential pathology does not manifest itself in practice.
W4 emphasise the importance of taking conjugated-melatonin according tothe recipe of ‘Di Bella-Ferrari’, in conjunction with other appropriate preventive therapies, designed in the etymological sense: i.e., to avoid tobacco smoke, sedentary lifestyle and overweight, and at the same time to favor an healthy lifestyle, using for instance a custom Mediterranean diet, encouraging a daily physical activity and body movement. It needs to be understood that the CAEMH reveals the state of suffering of the cell, particularly with respect to mitochondrial DNA, and thus the mitochondria,responsible for cell oxygenation. In case of alteration of mitochondrial DNA, it is clear that the mitochondrial oxygen becomes deficient. We are able to improve the mitochondrial respiration and functioning of the respiratory chain, i.e., the redox processes, reducing consequently the 'Congenital Real Risk'of cancer, if there was. Improving the mitochondrial respiration, or tissue oxygenation, we render harmless the risk of cancer. To give effect to this outcome over time, however, a continuous preventive therapy is needed. Manuel is the son of two parents both positive for 'OncologicalTerrain', but they agreed, at Stagnaro’s advice, to undergo a preventive therapy consisting ofetymologically speaking diet and in taking conjugated - melatonin 'Di Bella - Ferrari', beforebaby’s conception. After a few months of treatment, Stagnaro personally visited
Manuel, and I could see who was born without 'Oncological Terrain', though conceived by
both parents positive for TO. This means that Manuel will never become ill with cancer, even
in the presence of the several risk factors, and he will never surface in a 'real risk' of cancer.
References
1) Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [MEDLINE]
2) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Ed. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
3) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico- Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Ed. Travel Factory, Roma, 2004. http://www.travelfactory.it/libro_costituzionisemeiotiche.htm
4) Stagnaro S., Stagnaro-Neri M. Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Travel Factory, Roma, 2005. http://www.travelfactory.it/libro_singlepatientbased.htm
5) Stagnaro Sergio. Epidemiological evidence for the non-random clustering of the components of the metabolic syndrome: multicentre study of the Mediterranean Group for the Study of Diabetes. Eur J Clin Nutr. 2007 Feb 7; [MEDLINE]
6) Stagnaro Sergio. Pre-Metabolic Syndrome and Metabolic Syndrome: Biophysical-Semeiotic Viewpoint. www.athero.org, 29 April, 2009. http://www.athero.org/commentaries/comm904.asp
7) Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. www.athero.org, 29 April, 2009 http://www.athero.org/commentaries/comm907.asp
8) Simone Caramel and Sergio Stagnaro (2011) Quantum Chaotic Aspects of Biophysical Semeiotics - from JOQBS 1 28-70, 2011, http://www.sisbq.org/uploads/5/6/8/7/5687930/quantumchaotic_qbs.pdf
9) Simone Caramel and Sergio Stagnaro (2011) Quantum Biophysical Semeiotics of Oncological Inherited Real Risk of Myelopathy: The diagnostic role of glycocalyx. http://www.sisbq.org/uploads/5/6/8/7/5687930/qbs_myelopathy_glycocalyx_english.pdf
10) Simone Caramel and Sergio Stagnaro (2011) Quantum Biophysical Semeiotics and mit-Genome's fractal dimension Journal of Quantum Biophysical Semeiotics, 1 1-27,
http://www.sisbq.org/uploads/5/6/8/7/5687930/joqbs_mitgenome.pdf
11) Sergio Stagnaro The New War against Five Stages of type 2 Diabetes Mellitus. www.scivox.com, 12 December, 2011, http://www.sci-vox.com/stories/story/2011-01-12the+new+war+against+five+stages++of+type+2+diabetes+mellitus.html ; http://wwwshiphusemeioticscom-stagnaro.blogspot.com/2011/01/new-war-against-five-stages-of-type-2.html
12) Sergio Stagnaro. New Renaissance of Medicine. Type 2 Diabetes Mellitus Primary Prevention. http://qbsemeiotics.weebly.com/atti-del-convegno.html, 16 November, 2010; http://qbsemeiotics.weebly.com/uploads/5/6/8/7/5687930/report_stagnaro.pdf ; http://www.semeioticabiofisica.it/semeioticabiofisica/Documenti/Eng/Nuovo%20Rinascimento%20eng.doc
13) Sergio Stagnaro. Il I Stadio Semeiotico-Biofisico-Quantistico del Diabete Mellito:
Nosografia e Patogenesi. www.fce.it 17 novembre 2010. http://www.fceonline.it/images/docs/diagnosi%20diabete.pdf; http://qbsemeiotics.weebly.com/uploads/5/6/8/7/5687930/newrenaissance_prevenzionet2dm.pdf
14) Sergio Stagnaro. Ruolo del DNA Antenna nella Diagnosi Semeiotica Biofisica Quantistica dei Primi due Stadi del Diabete Mellito tipo 2. www.fce.it, 19 novembre 2010. http://www.fceonline.it/images/docs/dna_diabete.pdf; http://qbsemeiotics.weebly.com/uploads/5/6/8/7/5687930/dna_t2dm.pdf
15) Sergio Stagnaro. Siniscalchi's Sign. Bedside Recognizing, in one Second, Diabetic Constitution, its Inherited Real Risk, and Type 2 Diabetes Mellitus.
24 December, 2010, www.scivox.com, http://www.sci-vox.com/stories/story/2010-12-25siniscalchi%27signi.bedside++diagnosing+type+2+dm.html; www.sciphu.com; http://wwwshiphusemeioticscom-stagnaro.blogspot.com/
In the paper Authors* illustrate briefly the relation between right Planum Temporale dominance, Congenital Acidosic Enzyme-Metabolic Histangiopathy, and Quantum Biophysical Semeiotics Constitutions-Dependent Inherited Real Risks. In addition, Authors emphasise the possibility of bedside recognizing these congenital alterations, starting since birth. Finally, the efficacious Primary Prevention of most common and dangerous disorders is described.
* Sergio Stagnaro, and Simone Caramel
Editors,
in spite of an awful number of papers, one may reading the Literature since 32 years, the right dominant Planum Temporale, typical of Congenital Acidosic Enzyme-Metabolic Histangiopathy, a congenital mitochondrial cytopathy, quantum biohysical semeiotic Constitutions, and thus the relatedInherited Real Risk, bedside recognised with a stethoscope, are based on, is either overlooked or ignored by the majority of physicians, including neurologists. (1-8)
Quantum Biophysics Semeiotics,QBS, is a new discipline in medical field, extension of the classical semeiotics with the support of quantum and complexity theories, a scientific approach first described by Stagnaro (1-8) based on the 'Congenital Acidosic Enzyme-Metabolic Histangiopathy , CAEMH (1-4), a unique mitochondrial cytopathy, present at birth and subject to medical therapy.
According to the research of Stagnaro, today doctors should be able to evaluate, at the bedside, simply using the stethoscope and auscultatory percussion of the stomach (2), mitochondria functionality, as well as thefunctionality of all biological systems. It is now possible, since the moment of birth, to make adiagnosis in order to detect the presence of the Inherited Real Risk of many diseases linked with QBS Constitutions (3), so that an intelligent prevention strategy can be
implemented only on those subjects with Inherited Real Risk.
According to Stagnaro (2-5, 8-10), genome's information are transmitted simultaneously both to parenchyma and related micro-vessels, so that mutations in parenchymal cell n-DNA
and mit-DNA are the conditio sine qua non of the most common human disorders, like diabetes, CAD, and cancer, today's epidemics.
In fact, all these diseases are based on a particular congenital, functional, mitochondrial cytopathy, mostly transmitted through mother, and defined 'Congenital Acidosic Enzyme-
Metabolic Histangiopathy' - CAEMH (8-10).
Quantum Biophysical Semeiotics, in addition to the most severe disease diagnosis as, for example, many solid and liquid forms of cancer, type 2 diabetes mellitus, heart diseases, hypertension, osteoporosis, is concerned to suggest preventive therapies so that, especially in those at risk for some diseases, the still potential pathology does not manifest itself in practice.
W4 emphasise the importance of taking conjugated-melatonin according tothe recipe of ‘Di Bella-Ferrari’, in conjunction with other appropriate preventive therapies, designed in the etymological sense: i.e., to avoid tobacco smoke, sedentary lifestyle and overweight, and at the same time to favor an healthy lifestyle, using for instance a custom Mediterranean diet, encouraging a daily physical activity and body movement. It needs to be understood that the CAEMH reveals the state of suffering of the cell, particularly with respect to mitochondrial DNA, and thus the mitochondria,responsible for cell oxygenation. In case of alteration of mitochondrial DNA, it is clear that the mitochondrial oxygen becomes deficient. We are able to improve the mitochondrial respiration and functioning of the respiratory chain, i.e., the redox processes, reducing consequently the 'Congenital Real Risk'of cancer, if there was. Improving the mitochondrial respiration, or tissue oxygenation, we render harmless the risk of cancer. To give effect to this outcome over time, however, a continuous preventive therapy is needed. Manuel is the son of two parents both positive for 'OncologicalTerrain', but they agreed, at Stagnaro’s advice, to undergo a preventive therapy consisting ofetymologically speaking diet and in taking conjugated - melatonin 'Di Bella - Ferrari', beforebaby’s conception. After a few months of treatment, Stagnaro personally visited
Manuel, and I could see who was born without 'Oncological Terrain', though conceived by
both parents positive for TO. This means that Manuel will never become ill with cancer, even
in the presence of the several risk factors, and he will never surface in a 'real risk' of cancer.
References
1) Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [MEDLINE]
2) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Ed. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
3) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico- Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Ed. Travel Factory, Roma, 2004. http://www.travelfactory.it/libro_costituzionisemeiotiche.htm
4) Stagnaro S., Stagnaro-Neri M. Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Travel Factory, Roma, 2005. http://www.travelfactory.it/libro_singlepatientbased.htm
5) Stagnaro Sergio. Epidemiological evidence for the non-random clustering of the components of the metabolic syndrome: multicentre study of the Mediterranean Group for the Study of Diabetes. Eur J Clin Nutr. 2007 Feb 7; [MEDLINE]
6) Stagnaro Sergio. Pre-Metabolic Syndrome and Metabolic Syndrome: Biophysical-Semeiotic Viewpoint. www.athero.org, 29 April, 2009. http://www.athero.org/commentaries/comm904.asp
7) Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. www.athero.org, 29 April, 2009 http://www.athero.org/commentaries/comm907.asp
8) Simone Caramel and Sergio Stagnaro (2011) Quantum Chaotic Aspects of Biophysical Semeiotics - from JOQBS 1 28-70, 2011, http://www.sisbq.org/uploads/5/6/8/7/5687930/quantumchaotic_qbs.pdf
9) Simone Caramel and Sergio Stagnaro (2011) Quantum Biophysical Semeiotics of Oncological Inherited Real Risk of Myelopathy: The diagnostic role of glycocalyx. http://www.sisbq.org/uploads/5/6/8/7/5687930/qbs_myelopathy_glycocalyx_english.pdf
10) Simone Caramel and Sergio Stagnaro (2011) Quantum Biophysical Semeiotics and mit-Genome's fractal dimension Journal of Quantum Biophysical Semeiotics, 1 1-27,
http://www.sisbq.org/uploads/5/6/8/7/5687930/joqbs_mitgenome.pdf
11) Sergio Stagnaro The New War against Five Stages of type 2 Diabetes Mellitus. www.scivox.com, 12 December, 2011, http://www.sci-vox.com/stories/story/2011-01-12the+new+war+against+five+stages++of+type+2+diabetes+mellitus.html ; http://wwwshiphusemeioticscom-stagnaro.blogspot.com/2011/01/new-war-against-five-stages-of-type-2.html
12) Sergio Stagnaro. New Renaissance of Medicine. Type 2 Diabetes Mellitus Primary Prevention. http://qbsemeiotics.weebly.com/atti-del-convegno.html, 16 November, 2010; http://qbsemeiotics.weebly.com/uploads/5/6/8/7/5687930/report_stagnaro.pdf ; http://www.semeioticabiofisica.it/semeioticabiofisica/Documenti/Eng/Nuovo%20Rinascimento%20eng.doc
13) Sergio Stagnaro. Il I Stadio Semeiotico-Biofisico-Quantistico del Diabete Mellito:
Nosografia e Patogenesi. www.fce.it 17 novembre 2010. http://www.fceonline.it/images/docs/diagnosi%20diabete.pdf; http://qbsemeiotics.weebly.com/uploads/5/6/8/7/5687930/newrenaissance_prevenzionet2dm.pdf
14) Sergio Stagnaro. Ruolo del DNA Antenna nella Diagnosi Semeiotica Biofisica Quantistica dei Primi due Stadi del Diabete Mellito tipo 2. www.fce.it, 19 novembre 2010. http://www.fceonline.it/images/docs/dna_diabete.pdf; http://qbsemeiotics.weebly.com/uploads/5/6/8/7/5687930/dna_t2dm.pdf
15) Sergio Stagnaro. Siniscalchi's Sign. Bedside Recognizing, in one Second, Diabetic Constitution, its Inherited Real Risk, and Type 2 Diabetes Mellitus.
24 December, 2010, www.scivox.com, http://www.sci-vox.com/stories/story/2010-12-25siniscalchi%27signi.bedside++diagnosing+type+2+dm.html; www.sciphu.com; http://wwwshiphusemeioticscom-stagnaro.blogspot.com/
martedì 11 gennaio 2011
The New War against Five Stages of type 2 Diabetes Mellitus
According to WHO competent Authorities, there were in 2010 250 milion of diabetics, and they will be 366 milion in 2030, indicating that type 2 DM is today's growing epidemics (1-16).
In my opinion, as far as diabetes is concerned, primary prevention, especially when initiated in the first two stages among the five of th natural history of the disease, is far better than therapy, as usually.
Unforunately, Diabetic "and" Dislipidemic Constitutions, conditio sine qua non of type 2 DM, are nowadays overlooked by the majority of physicians all around the world (12-14). A long well westablished clinical experience allows me to state that with the aid of Quantum Biophysical Semeiotics, physicians can quickly and easili bedside recognize the "microcirculatory remodelling", based on newborn-pathological, subtype a) oncological , and b), aspecific, type I, Endoarteriolar Blocking Devices in tissue, wherein does really exist the inherited real risk of human common and severe diseases, as diabetes (12-16).
Obviously that happens in individuals with defined Biophysical Semeiotics Constitutions, in our case, Diabetic “and” Dislipidaemic, according to Joslin(1-6, 12-16).
To realize on vast scale Diabetes Primary Prevention (PP),enrolling exclusively individuals at Inherited Real Risk, we need new clinical tools, aiming to lower the increasing number of patients, because the present, expensive screening has failed (14). For instance, in the normal Langheran’s islets microcirculatory bed, there are exclusively “normal” type II (= in arterioles, according to Hammersen), but not type I (= in small arterioles) endoarteriolar blocking devices, i.e. EBD, of first and second classes, according to S.B.Curri (See http://www.semeioticabiofisica.it/microangiologia). In health, i.e., not involved by Diabetic Constitution, we cannot observe type I, newborn- pathological, EBD in above-mentioned biological system. On the contrary, in individuals involved by diabetic constitution as well as diabetic "Inherited Real Risk" and overt diabetes, of course, we observe with the aid of Quantum Biophysical Semeiotics also type I, newborn-pathological, subtype b) a-specific , EBD, facilitating the diagnosis and consequently diabetes primary prevention. In addition, the evaluation of Insulin Secretion Acute Pick Renal Test is significantly impaired, corroborating the clinical diagnosis (1-3) (See above cited- website, Practical Applications, and Glossary). Finally, an interesting clinical tool in recognizing diabetic constitution -dependent inherited real risk, as well as in diagnosing diabetes since early stages and diabetic monitoring proved to be bedside Biophysical-Semeiotic Osteocalcin Test and Siniscalchi's Sign (10, 15, 16).
As a matter of fact, Pre-hypertension during Young Adulthood may be involved by Coronary Calcium Later in Life exclusively in presence of Inherited Real Risk of CAD, typical for individuals with lithyasic Constitution, present in about 50% OF ALL CASES OF Pre-Metabolic and Metabolic Syndrome (www.semeioticabiofisica.it; Constitutions and Bibliography). Considering the frequent association between hypertension and diabetes, more important, in my opinion based on 53-year-long clinical experience, is bedside recognizing diabetic predisposition, now-a-days possible since birth, utilising a lot of methods, different in difficulty, but all reliable. For the first time, from the clinical view-point, I have recently illustrated an original manoeuvre, based on a singular activity of osteocalcin, and reliable in bedside detecting diabetes in one minute, with the aid of a stethoscope (10). In fact, osteocalcin, a product of osteoblasts, among other action mechanisms, stimulates both insulin secretion and insulin receptor sensitivity. As a consequence, osteocalcin, secreted by above-mentioned bone cells during mean-intense lasting digital pressure – for instance – applied upon lumbar vertebrae, brings about increasing pancreatic diameters, i.e., technically speaking, type I, associated, Langherans’s islet microcirculatory activation, so that doctors assess pancreas size augmentation, which in health, lasts 10 seconds exactly (1-11). After that, pancreas diameters return to basal value for 3 sec. The second pancreas size increasing lasts 20 sec., and finally the third show the highest value: 30 sec. I terme such as clinical investigation. On the contrary, in case of diabetic constitution (3, 4, 11, 13) the first pancreas increasing persists normally (10 sec.), but both the second and the third are less than physiological ones (i.e., less than 20 sec. and respectively 30 sec.). In presence of intense inherited real risk of diabetes (6), such as impairment is greater. Finally, in case of diabetes the alteration is present already in the first evaluation, wherein duration appears less than 10 sec., inversely related with disorder seriousness. Subsequently, I have ascertained that Ronald’s Manoeuvre result pathological already in individuals involved by both Diabetic Constitution and Inherited Diabetic Real Risk (1-11). Interestingly, not only in examining subject, but also in all others, even if kilometers way from him (her), according to Lory’s experiment, based of no local realm in biological systems (12, 15), pancreas show identical modifications, allowing doctors to made clinical diagnosis until now impossible (1-15).
1)Stagnaro S., Stagnaro-Neri M. Valutazione percusso-ascoltatoria del Diabete Mellito. Aspetti teorici e pratici. Epat. 32, 131, 1986
2) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
3) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico- Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Travel Factory, Roma, 2004. http://www.travelfactory.it/libro_costituzionisemeiotiche.htm
4) Stagnaro S., Stagnaro-Neri M. Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Travel Factory, Roma, 2005. http://www.travelfactory.it/libro_singlepatientbased.htm
5) Stagnaro S. Pivotal role of Biophysical Semeiotic Constitutions in Primary Prevention. Cardiovascular Diabetology, 2:1, 2003 http://www.cardiab.com/content/2/1/13/comments#5753
6) Stagnaro S. Stagnaro Sergio. Newborn-pathological Endoarteriolar Blocking Devices in Diabetic and Dislipidaemic Constitution and Diabetes Primary Prevention. www.fce.it, http://www.fceonline.it/index.php?option=com_content&task=view&id=3736&Itemid=47
7) Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [Medline]
8) Stagnaro Sergio. New bedside way in Reducing mortality in diabetic men and women. Ann. Int. Med.2007. http://www.annals.org/cgi/eletters/0000605- 200708070-00167v1
9) Stagnaro Sergio. Single Patient Based Medicine: its paramount role in Future Medicine. Public Library of Science. http://medicine.plosjournals.org/perlserv/?request=read-response 2005
10) Stagnaro Sergio. Teoria Patogenetica Unificata, 2006, Ed. Travel Factory, Roma.
11) Stagnaro Sergio. Il test Semeiotico-Biofisico della Osteocalcina nella prevenzione primaria del diabete mellito. www.fce.it, http://www.fcenews.it/index.php?option=com_content&task=view&id=909&Itemid=47
12) Stagnaro Sergio e Paolo Manzelli. L’Esperimento di Lory. Scienza e Conoscenza, N° 23, 13 Marzo 2008. http://www.scienzaeconoscenza.it//articolo.php?id=17775
13) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it, Roma, Luglio 2009.
14) . Sergio Stagnaro. New Renaissance in Medicina. Prevenzione Primaria del Diabete Mellito tipo 2. Sito del Convegno, http://qbsemeiotics.weebly.com/atti-del-convegno.html, 16 novembre 2010; English version: http://qbsemeiotics.weebly.com/uploads/5/6/8/7/5687930/report_stagnaro.pdf
15) Sergio Stagnaro. Siniscalchi's Sign. Bedside Recognizing, in one Second, Diabetic Constitution, its Inherited Real Risk, and Type 2 Diabetes Mellitus.
24 December, 2010, www.scivox.com, http://www.sci-vox.com/stories/story/2010-12-25siniscalchi%27signi.bedside++diagnosing+type+2+dm.html; www.sciphu.com; http://wwwshiphusemeioticscom-stagnaro.blogspot.com/ Italian version: http://www.sisbq.org/uploads/5/6/8/7/5687930/segnodisiniscalchi.pdf
16) Caramel Simone. Primary Prevention of T2DM and Inherited Real Risk of Type 2 Diabetes Mellitus http://ilfattorec.altervista.org/T2DM.pdf
In my opinion, as far as diabetes is concerned, primary prevention, especially when initiated in the first two stages among the five of th natural history of the disease, is far better than therapy, as usually.
Unforunately, Diabetic "and" Dislipidemic Constitutions, conditio sine qua non of type 2 DM, are nowadays overlooked by the majority of physicians all around the world (12-14). A long well westablished clinical experience allows me to state that with the aid of Quantum Biophysical Semeiotics, physicians can quickly and easili bedside recognize the "microcirculatory remodelling", based on newborn-pathological, subtype a) oncological , and b), aspecific, type I, Endoarteriolar Blocking Devices in tissue, wherein does really exist the inherited real risk of human common and severe diseases, as diabetes (12-16).
Obviously that happens in individuals with defined Biophysical Semeiotics Constitutions, in our case, Diabetic “and” Dislipidaemic, according to Joslin(1-6, 12-16).
To realize on vast scale Diabetes Primary Prevention (PP),enrolling exclusively individuals at Inherited Real Risk, we need new clinical tools, aiming to lower the increasing number of patients, because the present, expensive screening has failed (14). For instance, in the normal Langheran’s islets microcirculatory bed, there are exclusively “normal” type II (= in arterioles, according to Hammersen), but not type I (= in small arterioles) endoarteriolar blocking devices, i.e. EBD, of first and second classes, according to S.B.Curri (See http://www.semeioticabiofisica.it/microangiologia). In health, i.e., not involved by Diabetic Constitution, we cannot observe type I, newborn- pathological, EBD in above-mentioned biological system. On the contrary, in individuals involved by diabetic constitution as well as diabetic "Inherited Real Risk" and overt diabetes, of course, we observe with the aid of Quantum Biophysical Semeiotics also type I, newborn-pathological, subtype b) a-specific , EBD, facilitating the diagnosis and consequently diabetes primary prevention. In addition, the evaluation of Insulin Secretion Acute Pick Renal Test is significantly impaired, corroborating the clinical diagnosis (1-3) (See above cited- website, Practical Applications, and Glossary). Finally, an interesting clinical tool in recognizing diabetic constitution -dependent inherited real risk, as well as in diagnosing diabetes since early stages and diabetic monitoring proved to be bedside Biophysical-Semeiotic Osteocalcin Test and Siniscalchi's Sign (10, 15, 16).
As a matter of fact, Pre-hypertension during Young Adulthood may be involved by Coronary Calcium Later in Life exclusively in presence of Inherited Real Risk of CAD, typical for individuals with lithyasic Constitution, present in about 50% OF ALL CASES OF Pre-Metabolic and Metabolic Syndrome (www.semeioticabiofisica.it; Constitutions and Bibliography). Considering the frequent association between hypertension and diabetes, more important, in my opinion based on 53-year-long clinical experience, is bedside recognizing diabetic predisposition, now-a-days possible since birth, utilising a lot of methods, different in difficulty, but all reliable. For the first time, from the clinical view-point, I have recently illustrated an original manoeuvre, based on a singular activity of osteocalcin, and reliable in bedside detecting diabetes in one minute, with the aid of a stethoscope (10). In fact, osteocalcin, a product of osteoblasts, among other action mechanisms, stimulates both insulin secretion and insulin receptor sensitivity. As a consequence, osteocalcin, secreted by above-mentioned bone cells during mean-intense lasting digital pressure – for instance – applied upon lumbar vertebrae, brings about increasing pancreatic diameters, i.e., technically speaking, type I, associated, Langherans’s islet microcirculatory activation, so that doctors assess pancreas size augmentation, which in health, lasts 10 seconds exactly (1-11). After that, pancreas diameters return to basal value for 3 sec. The second pancreas size increasing lasts 20 sec., and finally the third show the highest value: 30 sec. I terme such as clinical investigation. On the contrary, in case of diabetic constitution (3, 4, 11, 13) the first pancreas increasing persists normally (10 sec.), but both the second and the third are less than physiological ones (i.e., less than 20 sec. and respectively 30 sec.). In presence of intense inherited real risk of diabetes (6), such as impairment is greater. Finally, in case of diabetes the alteration is present already in the first evaluation, wherein duration appears less than 10 sec., inversely related with disorder seriousness. Subsequently, I have ascertained that Ronald’s Manoeuvre result pathological already in individuals involved by both Diabetic Constitution and Inherited Diabetic Real Risk (1-11). Interestingly, not only in examining subject, but also in all others, even if kilometers way from him (her), according to Lory’s experiment, based of no local realm in biological systems (12, 15), pancreas show identical modifications, allowing doctors to made clinical diagnosis until now impossible (1-15).
1)Stagnaro S., Stagnaro-Neri M. Valutazione percusso-ascoltatoria del Diabete Mellito. Aspetti teorici e pratici. Epat. 32, 131, 1986
2) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
3) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico- Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Travel Factory, Roma, 2004. http://www.travelfactory.it/libro_costituzionisemeiotiche.htm
4) Stagnaro S., Stagnaro-Neri M. Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Travel Factory, Roma, 2005. http://www.travelfactory.it/libro_singlepatientbased.htm
5) Stagnaro S. Pivotal role of Biophysical Semeiotic Constitutions in Primary Prevention. Cardiovascular Diabetology, 2:1, 2003 http://www.cardiab.com/content/2/1/13/comments#5753
6) Stagnaro S. Stagnaro Sergio. Newborn-pathological Endoarteriolar Blocking Devices in Diabetic and Dislipidaemic Constitution and Diabetes Primary Prevention. www.fce.it, http://www.fceonline.it/index.php?option=com_content&task=view&id=3736&Itemid=47
7) Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [Medline]
8) Stagnaro Sergio. New bedside way in Reducing mortality in diabetic men and women. Ann. Int. Med.2007. http://www.annals.org/cgi/eletters/0000605- 200708070-00167v1
9) Stagnaro Sergio. Single Patient Based Medicine: its paramount role in Future Medicine. Public Library of Science. http://medicine.plosjournals.org/perlserv/?request=read-response 2005
10) Stagnaro Sergio. Teoria Patogenetica Unificata, 2006, Ed. Travel Factory, Roma.
11) Stagnaro Sergio. Il test Semeiotico-Biofisico della Osteocalcina nella prevenzione primaria del diabete mellito. www.fce.it, http://www.fcenews.it/index.php?option=com_content&task=view&id=909&Itemid=47
12) Stagnaro Sergio e Paolo Manzelli. L’Esperimento di Lory. Scienza e Conoscenza, N° 23, 13 Marzo 2008. http://www.scienzaeconoscenza.it//articolo.php?id=17775
13) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it, Roma, Luglio 2009.
14) . Sergio Stagnaro. New Renaissance in Medicina. Prevenzione Primaria del Diabete Mellito tipo 2. Sito del Convegno, http://qbsemeiotics.weebly.com/atti-del-convegno.html, 16 novembre 2010; English version: http://qbsemeiotics.weebly.com/uploads/5/6/8/7/5687930/report_stagnaro.pdf
15) Sergio Stagnaro. Siniscalchi's Sign. Bedside Recognizing, in one Second, Diabetic Constitution, its Inherited Real Risk, and Type 2 Diabetes Mellitus.
24 December, 2010, www.scivox.com, http://www.sci-vox.com/stories/story/2010-12-25siniscalchi%27signi.bedside++diagnosing+type+2+dm.html; www.sciphu.com; http://wwwshiphusemeioticscom-stagnaro.blogspot.com/ Italian version: http://www.sisbq.org/uploads/5/6/8/7/5687930/segnodisiniscalchi.pdf
16) Caramel Simone. Primary Prevention of T2DM and Inherited Real Risk of Type 2 Diabetes Mellitus http://ilfattorec.altervista.org/T2DM.pdf
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