Functional Decline in Aging , Brain Inherited Real Risk, and Co Q10 Deficiency Syndrome.

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Dear Dr. Stagnaro,

Thank you for your presubmission inquiry. Unfortunately, the Editors did
not feel that submission of your manuscript to the Journal of Clinical
Investigation would be appropriate at this time.

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and we determined that it would not ultimately be successful upon formal
review. In making this decision we do not mean to imply a criticism of
the work, we simply question its appropriateness for the JCI.

We thank you for giving us the opportunity to read about your work, and
hope you are soon able to interest an alternate journal in your manuscript.

Sincerely,
Ushma S. Neill, Ph.D.
Executive Editor


In following, I would like emphasise briefly the central role of these quantum-biophysical-semeiotic-Constitution-Dependent, Inherited Real Risk of Brain also in aging people disease occurrence,especially if Co Q10 deficiency is present.

In my opinion, bedside quantum-biophysical-semeiotic diagnosis of Co Q10 deficiency syndrome, I have described earlier (1-5), and the topic of above-cited Letter to Editors, could be very helpful in risk stratification to predict functional decline in Older Adults.

In fact, I have demonstrated that doctors can clinically recognize with the aid of a stethoscope subjects involved by Ubidecarenone deficiency, even initial and symptomless, causing damage of tissues due to the increase levels of free radical (1-5).

Moreover, in my 55-long clinical experience, such as diagnosis, made clinically for the first time, proved to be really efficacious and reliable in avoiding dangerous administration of statine to individuals without clinical symptomatology, even involved by ubidecarenone deficiency, notoriously worsened by anti-cholesterolemic drugs.

In addition, physicians are able to recognize since birth whatever Constitution-Dependent Inherited quantum-biophysical-semeiotic Real Risk, including oncological, diabetic, and Alzheimer Disease one (5-8), based on microvascular remodelling, characterized by newborn-pathological, type I, subtype a), oncological, and b) aspecific Endoarteriolar Blocking Devices, which predispose to the related disorders.

Finally, only individuals with inherited cerebral quantum-biophysical-semeiotic Inherited Real Risk (5) may be involved by functional decline, like Alzheimer Disease (8), particularly in presence of Co Q10 deficincy syndrome.

References
1) Stagnaro-Neri M., Stagnaro S., Carenza di Co Q10 secondaria a terapia ipolipidemmizante diagnosticata con la Percussione Ascoltata. Settimana Italiana di Dietologia, 9-13 Aprile 1991, Merano. Atti, pg. 65. Epat. 37, 17, 1990.

2)Stagnaro-Neri M., Stagnaro S., Acidi grassi W-3, scavengers dei radicali liberi e attivatori del ciclo Q della sintesi del Co Q10. Gazz. Med. It. – Arch. Sc. Med. 151, 341, 1992.

3) Stagnaro-Neri M., Stagnaro S., Auscultatory Percussion Coenzyme Q deficiency Syndrome. VI Int. Symp., Biomedical and clinical aspects of Coenzyme Q. Rome, January 22.24, 1990,Chairmen K. Folkers, G.L. Littarru, T. Yamagani, Abs., pg. 105.

4) Stagnaro-Neri M., Stagnaro S., Sindrome clinica percusso-ascoltatoria da carenza di Co Q10. Medic. Geriatr. XXIV, 239.

5) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it, Roma, 2009.

6) Stagnaro S. Bedside diagnosis of osteoporotic constitution, real risk of inheriting ostoporosis, and finally osteoporosis. Theoretical Biology and Medical Modelling 21 June 2007. http://www.tbiomed.com/content/4/1/23/comments#285569

7) Stagnaro S. New bedside way in reducing mortality in diabetic men and women. Ann. Int. Med. . http://www.annals.org/cgi/eletters/0000605-200708070-00167v1

8) Stagnaro Sergio. Alzheimer's Disease Byophysical Semeiotics supports the pathophysiology of Koudinov's theory.11 January 2002. Clin. Med. & Health Research http://clinmed.netprints.org/cgi/eletters/2001100005v1#9

Do NEJM Editors know Oncological Terrain? Vitamine D and Cancer Primary Prevention. Oncological Terrain plays a central Role.

Do NEJM Editors know Oncological Terrain?
Vitamine D and Cancer Primary Prevention. Oncological Terrain plays a central Role.

The following Letter to Editors, date submitted 8 April, 2011 (Manuscript ID: 11-04116. Title:Vitamine D and Cancer. Oncological Terrain plays a central Role. Author: Stagnaro, Sergio. Date Submitted: 08-Apr-2011) has been rejected by NEJM the day 13 May, 2010.
Overlooking the Congenital Acidosic Enzyme-Metabolic Histangiopathy, at base of Oncological Terrain, "conditio sine qua non" of most dangerous human disorders, including malignancy is overlooked, primary preventions are fundamentally biased, and thus no efficacious (1-5). Environmental risk factors and drugs, suggested as cancer risk factors, influence human biological functions, bringing about different disorders, like cancers, exclusively in presence of CAEMH-Dependent Oncological Inherited Real Risk in a biological system. This overlooked functional mitochondrial cytopathology, quantum-biophysical-semeiotic constitutions are based on, is genetic factor of human disorders, including malignancy (1-5). I emphasise pathological negative influence of smoking and Vitamine D deficiency on biological systems (3, 4). This effect varies in prevalence and intensity among individuals in relation to the above-mentioned congenital mitochondrial cytopathology, (2). This "silent" and dangerous action is easy to evaluate at the bed-side with a stethoscope. Physician first investigates the presence of CAEMH in the "enrolled" individuals, and than assesses OT-Dependent Inherited Real Risk, based on above-mentioned congenital cytopathology, characterized by newborn-pathological, type I, subtype a), oncological, Endoarterial Blocking Devices, causing the typical microvascular remodelling (1-5).

References
1) Stagnaro S., Stagnaro-Neri M. Una patologia mitocondriale ignorata: la Istangiopatia Congenita Acidosica Enzimo-Metabolica. Gazz. Med. It. - Arch. Sci. Med. 1990;149: 67-69.

2) Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [MEDLINE]
3) Caramel S., Stagnaro S. The role of mitochondria and mit-DNA in Oncogenesis. http://ilfattorec.altervista.org/mitDNA&oncogenesis_english.pdf; http://www.quantumbiosystems.org/admin/files/QBS 2(1) 250-281.pdf.
4) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Ed. Travel Factory, Roma, 2004. http://www.travelfactory.it/
5) ) Stagnaro Sergio. Reale Rischio Semeiotico Biofisico. I Dispositivi Endoarteriolari di Blocco neoformati, patologici, tipo I, sottotipo a) oncologico, e b) aspecifico. Ediz. Travel Factory, www.travelfactory.it

Right Planum Temporale Dominance, Congenital Acidosic Enzyme-Metabolic Histangiopathy, Quantum Biophysical Semeiotic Constitutions-Dependent Inherited

Abstract.
In the paper Authors* illustrate briefly the relation between right Planum Temporale dominance, Congenital Acidosic Enzyme-Metabolic Histangiopathy, and Quantum Biophysical Semeiotics Constitutions-Dependent Inherited Real Risks. In addition, Authors emphasise the possibility of bedside recognizing these congenital alterations, starting since birth. Finally, the efficacious Primary Prevention of most common and dangerous disorders is described.

* Sergio Stagnaro, and Simone Caramel

Editors,
in spite of an awful number of papers, one may reading the Literature since 32 years, the right dominant Planum Temporale, typical of Congenital Acidosic Enzyme-Metabolic Histangiopathy, a congenital mitochondrial cytopathy, quantum biohysical semeiotic Constitutions, and thus the relatedInherited Real Risk, bedside recognised with a stethoscope, are based on, is either overlooked or ignored by the majority of physicians, including neurologists. (1-8)
Quantum Biophysics Semeiotics,QBS, is a new discipline in medical field, extension of the classical semeiotics with the support of quantum and complexity theories, a scientific approach first described by Stagnaro (1-8) based on the 'Congenital Acidosic Enzyme-Metabolic Histangiopathy , CAEMH (1-4), a unique mitochondrial cytopathy, present at birth and subject to medical therapy.
According to the research of Stagnaro, today doctors should be able to evaluate, at the bedside, simply using the stethoscope and auscultatory percussion of the stomach (2), mitochondria functionality, as well as thefunctionality of all biological systems. It is now possible, since the moment of birth, to make adiagnosis in order to detect the presence of the Inherited Real Risk of many diseases linked with QBS Constitutions (3), so that an intelligent prevention strategy can be
implemented only on those subjects with Inherited Real Risk.
According to Stagnaro (2-5, 8-10), genome's information are transmitted simultaneously both to parenchyma and related micro-vessels, so that mutations in parenchymal cell n-DNA
and mit-DNA are the conditio sine qua non of the most common human disorders, like diabetes, CAD, and cancer, today's epidemics.
In fact, all these diseases are based on a particular congenital, functional, mitochondrial cytopathy, mostly transmitted through mother, and defined 'Congenital Acidosic Enzyme-
Metabolic Histangiopathy' - CAEMH (8-10).
Quantum Biophysical Semeiotics, in addition to the most severe disease diagnosis as, for example, many solid and liquid forms of cancer, type 2 diabetes mellitus, heart diseases, hypertension, osteoporosis, is concerned to suggest preventive therapies so that, especially in those at risk for some diseases, the still potential pathology does not manifest itself in practice.
W4 emphasise the importance of taking conjugated-melatonin according tothe recipe of ‘Di Bella-Ferrari’, in conjunction with other appropriate preventive therapies, designed in the etymological sense: i.e., to avoid tobacco smoke, sedentary lifestyle and overweight, and at the same time to favor an healthy lifestyle, using for instance a custom Mediterranean diet, encouraging a daily physical activity and body movement. It needs to be understood that the CAEMH reveals the state of suffering of the cell, particularly with respect to mitochondrial DNA, and thus the mitochondria,responsible for cell oxygenation. In case of alteration of mitochondrial DNA, it is clear that the mitochondrial oxygen becomes deficient. We are able to improve the mitochondrial respiration and functioning of the respiratory chain, i.e., the redox processes, reducing consequently the 'Congenital Real Risk'of cancer, if there was. Improving the mitochondrial respiration, or tissue oxygenation, we render harmless the risk of cancer. To give effect to this outcome over time, however, a continuous preventive therapy is needed. Manuel is the son of two parents both positive for 'OncologicalTerrain', but they agreed, at Stagnaro’s advice, to undergo a preventive therapy consisting ofetymologically speaking diet and in taking conjugated - melatonin 'Di Bella - Ferrari', beforebaby’s conception. After a few months of treatment, Stagnaro personally visited
Manuel, and I could see who was born without 'Oncological Terrain', though conceived by
both parents positive for TO. This means that Manuel will never become ill with cancer, even
in the presence of the several risk factors, and he will never surface in a 'real risk' of cancer.

References

1) Stagnaro S., West PJ., Hu FB., Manson JE., Willett WC. Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. [MEDLINE]
2) Stagnaro-Neri M., Stagnaro S. Introduzione alla Semeiotica Biofisica. Il Terreno Oncologico. Ed. Travel Factory, Roma, 2004. http://www.travelfactory.it/semeiotica_biofisica.htm
3) Stagnaro S., Stagnaro-Neri M., Le Costituzioni Semeiotico- Biofisiche.Strumento clinico fondamentale per la prevenzione primaria e la definizione della Single Patient Based Medicine. Ed. Travel Factory, Roma, 2004. http://www.travelfactory.it/libro_costituzionisemeiotiche.htm
4) Stagnaro S., Stagnaro-Neri M. Single Patient Based Medicine.La Medicina Basata sul Singolo Paziente: Nuove Indicazioni della Melatonina. Travel Factory, Roma, 2005. http://www.travelfactory.it/libro_singlepatientbased.htm
5) Stagnaro Sergio. Epidemiological evidence for the non-random clustering of the components of the metabolic syndrome: multicentre study of the Mediterranean Group for the Study of Diabetes. Eur J Clin Nutr. 2007 Feb 7; [MEDLINE]
6) Stagnaro Sergio. Pre-Metabolic Syndrome and Metabolic Syndrome: Biophysical-Semeiotic Viewpoint. www.athero.org, 29 April, 2009. http://www.athero.org/commentaries/comm904.asp
7) Stagnaro Sergio. CAD Inherited Real Risk, Based on Newborn-Pathological, Type I, Subtype B, Aspecific, Coronary Endoarteriolar Blocking Devices. Diagnostic Role of Myocardial Oxygenation and Biophysical-Semeiotic Preconditioning. www.athero.org, 29 April, 2009 http://www.athero.org/commentaries/comm907.asp
8) Simone Caramel and Sergio Stagnaro (2011) Quantum Chaotic Aspects of Biophysical Semeiotics - from JOQBS 1 28-70, 2011, http://www.sisbq.org/uploads/5/6/8/7/5687930/quantumchaotic_qbs.pdf
9) Simone Caramel and Sergio Stagnaro (2011) Quantum Biophysical Semeiotics of Oncological Inherited Real Risk of Myelopathy: The diagnostic role of glycocalyx. http://www.sisbq.org/uploads/5/6/8/7/5687930/qbs_myelopathy_glycocalyx_english.pdf
10) Simone Caramel and Sergio Stagnaro (2011) Quantum Biophysical Semeiotics and mit-Genome's fractal dimension Journal of Quantum Biophysical Semeiotics, 1 1-27,
http://www.sisbq.org/uploads/5/6/8/7/5687930/joqbs_mitgenome.pdf
11) Sergio Stagnaro The New War against Five Stages of type 2 Diabetes Mellitus. www.scivox.com, 12 December, 2011, http://www.sci-vox.com/stories/story/2011-01-12the+new+war+against+five+stages++of+type+2+diabetes+mellitus.html ; http://wwwshiphusemeioticscom-stagnaro.blogspot.com/2011/01/new-war-against-five-stages-of-type-2.html
12) Sergio Stagnaro. New Renaissance of Medicine. Type 2 Diabetes Mellitus Primary Prevention. http://qbsemeiotics.weebly.com/atti-del-convegno.html, 16 November, 2010; http://qbsemeiotics.weebly.com/uploads/5/6/8/7/5687930/report_stagnaro.pdf ; http://www.semeioticabiofisica.it/semeioticabiofisica/Documenti/Eng/Nuovo%20Rinascimento%20eng.doc
13) Sergio Stagnaro. Il I Stadio Semeiotico-Biofisico-Quantistico del Diabete Mellito:
Nosografia e Patogenesi. www.fce.it 17 novembre 2010. http://www.fceonline.it/images/docs/diagnosi%20diabete.pdf; http://qbsemeiotics.weebly.com/uploads/5/6/8/7/5687930/newrenaissance_prevenzionet2dm.pdf
14) Sergio Stagnaro. Ruolo del DNA Antenna nella Diagnosi Semeiotica Biofisica Quantistica dei Primi due Stadi del Diabete Mellito tipo 2. www.fce.it, 19 novembre 2010. http://www.fceonline.it/images/docs/dna_diabete.pdf; http://qbsemeiotics.weebly.com/uploads/5/6/8/7/5687930/dna_t2dm.pdf
15) Sergio Stagnaro. Siniscalchi's Sign. Bedside Recognizing, in one Second, Diabetic Constitution, its Inherited Real Risk, and Type 2 Diabetes Mellitus.
24 December, 2010, www.scivox.com, http://www.sci-vox.com/stories/story/2010-12-25siniscalchi%27signi.bedside++diagnosing+type+2+dm.html; www.sciphu.com; http://wwwshiphusemeioticscom-stagnaro.blogspot.com/